Contact mail: pmi@pie.nl


The novel angio-based functional lesion assessment: wire and adenosine free

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The vFFR workflow builds a 3D reconstruction of coronary artery and assesses pressure drop, resulting in a vFFR value. Furthermore, the 3D reconstruction enables assessment of severity and percentage of stenosis.

Functional lesion information

  • Pressure drops in coronary artery
  • vFFR value

Anatomical lesion information

  • Lesion diameter
  • Percentage stenosis
  • Reference diameter
  • Obstruction length
Clinical Evidence
  • vFFR is subject of two multi-center randomized clinical trials investigating the effectiveness of vFFR guided revascularization vs FFR guided revascularization in over 4000 patients:
  • vFFR is and has been subject to multiple single and multi-center trials investigating diagnostic accuracy to predict FFR ≤ 0.8, accuracy in post-PCI setting and accuracy related to IVUS, OCT, NHPR. A full overview can be found here.


Key product features
  • Angiographically derived pressure drop and vFFR value
  • Fits seamlessly in normal cathlab workflow using just 2 contrast filled angiograms
  • Vendor independent: compatible with most X-ray systems

Pressure drop in the coronary arteries


  • Masdjedi K, Van Zandvoort L, Balbi M, Gijsen F, Ligthart J, Rutten M, Lemmert M, Wildschut J, Diletti R, Zijlstra F, Van Mieghem N, Daemen J. Validation of 3-Dimensional Quantitative Coronary Angiography based software to calculate Fractional Flow Reserve: Fast Assessment of STenosis severity (FAST)-study. EuroIntervention 2019; Jaa-580 2019, doi: 10.4244/EIJ-D-19-00466
  • Masdjedi K, Tanaka N, Van Belle E, Porouchani S, Linke A, Woitek F, Bartorelli A, Ali Z, den Dekker W, Wilschut J, Diletti R, Zijlstra F, Boersma E, Van Mieghem M, Spitzer E, Daemen J.  Vessel Fractional Flow Reserve (vFFR) for the assessment of stenosis severity: the FAST II study. EuroIntervention 2021; 17, doi: 10.4244/EIJ-D-21-00471 .
  • Neleman T, Masdjedi K, Van Zandvoort LJC, Tomaniak M, Ligthart JMR, Witberg KT, Vermaire AA, Boersma E, Van Mieghem NM, Daemen J. Extended Validation of Novel 3D Quantitative Coronary Angiography-Based Software to Calculate vFFR: The FAST EXTEND Study. JACC Cardiovasc Imaging. 2021 Feb;14(2):504-506. doi: 10.1016/j.jcmg.2020.08.006. Epub 2020 Sep 30. PMID: 33011122.
  • Masdjedi, K, van Zandvoort, LJ, Balbi, MM, et al. Validation of novel 3‐dimensional quantitative coronary angiography based software to calculate fractional flow reserve post stenting. Catheter Cardiovasc Interv. 2020; 1– 7. https://doi.org/10.1002/ccd.29311
  • Tomaniak, M, Masdjedi, K, van Zandvoort, LJ, et al. Correlation between 3D‐QCA based FFR and quantitative lumen assessment by IVUS for left main coronary artery stenoses. Catheter Cardiovasc Interv. 2020; 1– 7. https://doi.org/10.1002/ccd.29151

Why choose us?

We always aim to improve the quality and efficiency of cardiovascular image analysis to optimize patient treatment. To realize this, we:

  • Provide fast and user-friendly software;
  • Align our product portfolio with the latest developments in the cardiovascular field. In this way we aim to provide our customers with the optimal software solution at the right time;
  • Offer training options which can be tailored to your needs.

We believe in the importance of training and support to assure that all our users are proficient and comfortable with their analysis. Please visit our Training & Support page for more information.