The QCA 3D (3 dimensional Quantitative Coronary Analysis) workflow allows 3D analysis of single and bifurcated coronary arteries based on multiple angiographic X-ray projections. These projections are used to calculate the true geometric shape in 3D space and create an interactive rendered view of the artery of interest.

Key Product Features

  • Quantification of lesion length and percentage stenosis in a 3D reconstruction
  • Elimination of foreshortening and out-of-plane magnification errors
  • Interactive 3D rendered view for assessment of shape
  • Full automatic calibration: this eliminates the need for manual input

QCA 3D for Research

QCA 3D can be extended with research functionality. In the QCA 3D for research workflow, specific additional functionality for both single vessel and bifurcation analysis is provided. Drug Eluting Stent (DES) analysis enables the user to evaluate restenosis and edge effects in pre-, post- and follow-up studies. With User Defined Subsegments (UDS), the vessel of interest can be divided in multiple subsegments and the curvature of these subsegments can be determined. UDS can for example be used in studies on biodegradable stents.  With the Bifurcation 6- and 11-Segment Model (BSM) implanted bifurcation stents can be quickly compared in pre-, post- and follow-up studies. All measurements are calculated on a 3D reconstruction with the true geometric shape.

Extra Key Product Features in QCA 3D Research

  • Results of evaluation of auto subsegment analysis
  • 6 and 11 subsegment analysis for bifurcation vessels

QCA3D with IVUS/OCT co-registration

QCA3D can be co-registered real time with IVUS or OCT pullbacks. Using this co-registration technology 3D coronary anatomy based on angiography can be aligned with the coronary anatomy as visualized in IVUS or OCT pullbacks.

Co-registration can be performed with INDEC EchoPlaque.

Key product features

  • 3D reconstruction of coronary artery from two angiograms.
  • Two way co-registration of angiography with IVUS / OCT.
  • Perform length, distance and area measurements
  • Add bookmarks to indicate important vessel sections.
  • Full access to all functionalities in QCA 3D or INDEC echoPlaque.

For a more automated co-registration workflow see CAAS WS IV-LINQ.

Co-registration is available for research use only.

Key results

  • 3D bifurcation angles
  • Minimum luminal diameter
  • Reference diameter
  • % Diameter stenosis
  • Length stenotic segment

QCA 3D for Research

Extra Key Results in QCA 3D for research

  • Results of evaluation of auto subsegment analysis
  • 6 and 11 subsegment analysis for bifurcation vessels

QCA 3D with IVUS/OCT co-registration

With Co-registration, angiography can be viewed side by side with the IVUS or OCT images to get a detailed view of the lesion and its exact location in the coronary tree.

  • Perform length, distance, area measurements
  • Add bookmarks to indicate important vessel sections

Key Publications

  • Grundeken M et al. Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography: A subgroup analysis of the Tryton IDE randomized trial 2016: Catheterization and Cardiovascular Interventions.
  • Schrauwen JT, Karanasos A, van Ditzhuijzen NS, Aben JP, van der Steen AF, Wentzel JJ, Gijsen FJ. Influence of the Accuracy of Angiography-Based Reconstructions on Velocity and Wall Shear Stress Computations in Coronary Bifurcations: A Phantom Study. PLoS One 2015; ­10 (12).
  • Muramatsu T, Grundeken MJ, Ishibashi Y, Nakatani S, Girasis C, Campos CM, Morel M, Jonker H, Winter RJ, Wykrzykowska JJ, Garcia-Garcia HM, Leon MB, Serruys PW, Onuma Y. Comparison between two- and three-dimensional quantitative coronary angiography bifurcation analyses for the assessment of bifurcation lesions: A subanalysis of the Tryton Pivotal IDE Coronary Bifurcation Trial. Catheter Cardiovasc Interv 2015.
  • Girasis C, Schuurbiers JCH, Marumatsu T, Aben JP, Onuma Y, Soekhradj S, Morel MA, Van Geuns RJ, Wentzel JJ and Serruys PW. Advanced three-dimensional quantitative coronary angiographic assessment of bifurcation lesions: methodology and phantom validation. EuroIntervention 2013; 8: 1451-1460
  • Schuurbiers JCH, Lopez NG, Ligthart J, Gijsen, FJH, Dijkstra J, Serruys PW, van der Steen AF and Wentzel JJ. In vivo validation of CAAS QCA-3D coronary reconstruction using fusion of angiography and intravascular ultrasound (ANGUS). Catheter Cardiovasc Interv 2009; 73(5): 620-6
  • Ramcharitar S, Daemen J, Patterson M, Van Geuns RJ, Boersma E, Serruys PW and Van der Giessen W. First direct in vivo comparison of two commercially available three-dimensional quantitative coronary angiography systems. Catherization and Cardiovascular Interventions 2009; 71: 44-50
  • Rzeszutko LJ, Partyka L, Roman LW, Tijdens F, Barycz G, Slots T, Nyssen V, Kaluza G and Dariusz D. Accuracy and precision of a novel 3D angiographic reconstruction and quantification software (CAAS QCA 3D) in measuring intracoronary length using marker wire in angioplasty patients. TCT 2007
  • Onuma Y, Girasis C, Aben JP, Sarno G, Piazza N, Lokkerbol C, Morel MA, Serruys PW. A novel dedicated 3-dimensional quantitative coronary analysis methodology for bifurcation lesions. Eurointervention 2011.

QCA 3D with IVUS/OCT co-registration

  • Ligthart J, Witzberg K, Slots T, Karanasos A, Regar E, Assessment of Co-Registration between 3D Angiography and IVUS. An In Vivo Feasability Study. Poster presentation 2103-306 ACC Washington DC (2014).